Asiaticoside enhances the antitumor efficacy of MSLN-targeted CAR-T cells in ovarian cancer
Our findings demonstrate that AC alleviates CAR-T cell exhaustion and antagonizes TGF-β-mediated immunosuppression. AC represents a promising, clinically translatable pharmacological adjuvant to overcome the bottlenecks of CAR-T cell therapy in solid tumors.
Authors
- Xifeng Pan
- Wanli Yang (ORCID: https://orcid.org/0000-0003-0666-8063)
- Xiaodong Li (ORCID: https://orcid.org/0000-0003-2348-926X)
- Gan Huang (ORCID: https://orcid.org/0000-0002-7595-973X)
- Juanwen Cao
- Yuyan Xie
- Dan Zou
- Wei Jiang
- Bonan Sun
- Miaomiao Yu
- Yu Tang
- Qi Li
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Zhejiang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1186/s12967-026-08053-w
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00