Pathological Complete Response after Surgery following Chemotherapy with Immune Checkpoint Inhibitors for Gastric Cancer with Liver Metastases: Two Case Reports

INTRODUCTION: In recent years, advances in pharmacotherapy, including the introduction of immune checkpoint inhibitors (ICIs), have affected treatment strategies for advanced gastric cancer. Surgical intervention after systemic therapy has the potential to improve the prognosis of patients with advanced gastric cancer and liver metastases. Herein, we report two cases in which gastrectomy and hepatectomy were performed after pharmacotherapy with ICIs, resulting in a pathological complete response.

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Publication Details

Journal
Surgical Case Reports
Published
2026-01-01
DOI
https://doi.org/10.70352/scrj.cr.25-0649
Primary Topic
Gastric Cancer Management and Outcomes
Type
article
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Pathological Complete Response after Surgery following Chemotherapy with Immune Checkpoint Inhibitors for Gastric Cancer with Liver Metastases: Two Case Reports

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Pathological Complete Response after Surgery following Chemotherapy with Immune Checkpoint Inhibitors for Gastric Cancer with Liver Metastases: Two Case Reports

Tamotsu Sugai, Soshi Hori, Noriyuki Uesugi, M. Suzuki, Kazuki NISHINO, Hirohito Kakinuma, Michitaka Honda, Ryuya Yamamoto, Nobuyasu Suzuki, Kaho Koide
article en

Abstract

INTRODUCTION: In recent years, advances in pharmacotherapy, including the introduction of immune checkpoint inhibitors (ICIs), have affected treatment strategies for advanced gastric cancer. Surgical intervention after systemic therapy has the potential to improve the prognosis of patients with advanced gastric cancer and liver metastases. Herein, we report two cases in which gastrectomy and hepatectomy were performed after pharmacotherapy with ICIs, resulting in a pathological complete response.

Surgical Case ReportsVol. 12(1)
Fukushima Medical University (JP), Southern Tohoku General Hospital (JP)
Good health and well-being
Openalex Percentile: Top 7%
Gastric Cancer Management and Outcomes
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