Circulating amino acids and Type 2 diabetes in a Latin American population-based cohort
Elevated plasma BCAA concentrations in Chilean adults were significantly associated with the prevalence of T2D, while only high isoleucine was associated with the incidence of T2D. These findings could inform risk stratification by specific metabolic mechanisms and guide future research on targeted interventions.
Authors
- Andrea Huidobro (ORCID: https://orcid.org/0000-0001-6179-6688)
- J. D. R. Connolly
- F. Ayala‐Paredes (ORCID: https://orcid.org/0000-0003-0670-6066)
- José Luis Santos (ORCID: https://orcid.org/0000-0003-4074-8059)
- Sandra Isabel Cortés
- Franco Godoy
- Catterina Ferreccio
- Sebastian Cofré
- Hakon Hakonarson
- Hui-Qi Qu
- Claudia Bambs
Institutions
- Children's Hospital of Philadelphia (US)
- Pontificia Universidad Católica de Chile (CL)
- University of Iceland (IS)
- Catholic University of the Maule (CL)
- Centre For Sustainable Urban Development (CL)
- Ministry of Health (CL)
- Navarre Institute of Health Research (ES)
- Advanced Center for Chronic Diseases (CL)
- University of Pennsylvania (US)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1186/s12933-026-03146-8
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00