Metabolic engineering of Streptomyces albulus for de novo serotonin production
This work establishes S. albulus as an efficient microbial platform for high-level 5-HT production. The engineered strain and optimized fermentation process demonstrate strong potential for industrial application and provide a versatile chassis for synthesizing diverse tryptophan-derived bioactive compounds.
Authors
- Xiuwen Wang (ORCID: https://orcid.org/0000-0003-0623-808X)
- Ao Liu (ORCID: https://orcid.org/0000-0003-2232-1633)
- M D Zhang
- Linghui Kong (ORCID: https://orcid.org/0009-0002-0526-9183)
- Qingshou Yao (ORCID: https://orcid.org/0009-0004-8808-2211)
- Jiabei Song
- Jiayang Qin
- Yuan Zhang
- Qian Wang
- Yongxuan Liu
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Wenzhou Institute of Technology Testing & Calibration (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1186/s12934-026-02995-y
- Primary Topic
- Biochemical and biochemical processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00