Transforming colorectal health: A clinical diagnostic model for sessile serrated lesions detection

ObjectiveThis study aimed to identify the clinical risk factors for colorectal sessile serrated lesions and to develop a diagnostic model to facilitate clinical diagnosis.MethodsPatients who underwent electronic colonoscopy during hospitalization between June 2021 and June 2024 were enrolled. General clinical data were collected for univariate and multivariate logistic regression analyses. A nomogram-based risk prediction model was developed using R language software.ResultsCompared with patients without abnormalities on colonoscopy, those with colorectal sessile serrated lesions showed statistically significant differences in male sex, history of smoking, history of hypertension, and higher body mass index (p<i> </i><<i> </i>0.05). Multivariate logistic regression analysis demonstrated that a history of smoking and hypertension were independent risk factors for colorectal sessile serrated lesions, with odds ratios of 3.761 (95% confidence interval: 1.795-7.880; p<i> </i>=<i> </i>0.000) and 1.919 (95% confidence interval: 1.026-3.589; p<i> </i>=<i> </i>0.041), respectively.ConclusionsA history of smoking and hypertension were identified as independent risk factors for colorectal sessile serrated lesions. Increased attention should be given to screening for colorectal sessile serrated lesions in patients with these risk factors.