The effects of resistance training on myostatin in older adults with frailty and/or sarcopenia: a systematic review and meta analysis

Very low-certainty evidence from this meta-analysis suggests that RT may be associated with a reduction in serum MSTN concentrations in frail or sarcopenic older adults, with a more consistent effect observed in those with sarcopenia. These findings highlight the potential of RT as a non-pharmacological strategy, but further high-quality trials are needed to confirm its efficacy and establish optimal training parameters.