Dynamic Brain [F18]-Fluoroestradiol (FES) PET Protocol Optimization for Improved Detection of Breast Cancer Brain Metastases
Time window-3 at 60-75 minutes post-injection provided optimal LMR for brain [<sup>18</sup>F]FES PET in ER<sup>+</sup> BC and suspected BM. Imaging beyond this interval may not further improve diagnostic yield and may reduce visibility. Limitations of this study include small cohort size, population heterogeneity with regard to prior treatment, and lack of pathologic confirmation. Our findings suggest that 60-75 minutes post-injection may represent the optimal acquisition time window and highlight the importance of timing standardization for neuro-oncologic applications of brain [<sup>18</sup>F]FES PET.
Authors
- Arman Sharbatdaran (ORCID: https://orcid.org/0000-0002-7097-0032)
- Jonathan P. Dyke (ORCID: https://orcid.org/0000-0001-7170-488X)
- Nicholas DiGregorio
- Sadek A. Nehmeh (ORCID: https://orcid.org/0000-0002-3129-5003)
- Jolie Jean (ORCID: https://orcid.org/0000-0003-0006-9158)
- Letizia Pontolillo (ORCID: https://orcid.org/0009-0006-3363-8512)
- Ezzat Elmoujarkach (ORCID: https://orcid.org/0000-0003-2750-5984)
- Jonathan P.S. Knisely
- Eleni Andreopoulou
- Rajiv Magge
- Kathryn Beal
- Jana Ivanidze
- Matthew Agee
- Rohan Ramakrishna
- Massimo Cristofanilli
- Susan Pannullo
Institutions
- Cornell University (US)
- Presbyterian Hospital (US)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.3174/ajnr.a9316
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00