Complete Atelectasis of Left Lung due to Methotrexate-associated Lymphoproliferative Disorder: A Case Report
A 59-year-old man who had been treated with methotrexate (MTX) for rheumatoid arthritis was referred to our hospital because of dyspnea. Chest computed tomography revealed a mass obstructing the left main bronchus and complete atelectasis of the left lung. Histopathology of the tumor obtained by trans-bronchial biopsies showed lymphoproliferative disorder (LPD) with positive results for Epstein-Barr virus-encoded small ribonucleic acid in situ hybridization. Withdrawal of MTX resulted in remission of both the tumor and atelectasis, supporting the diagnosis of MTX-associated LPD (MTX-LPD). We herein report a rare case of MTX-LPD with complete atelectasis of a unilateral lung.
Authors
- Hiroto Murao
- Akiyoshi Takami (ORCID: https://orcid.org/0000-0002-1822-9976)
- Taishi Takahara (ORCID: https://orcid.org/0000-0001-9219-8357)
- Toshiyuki Yonezawa
- Satoru Ito (ORCID: https://orcid.org/0000-0001-7885-4653)
- Satsuki Murakami
- Saori Onishi
- Toyonori Tsuzuki
- Chisako Udo
- Yuka Onda
Institutions
- Aichi Medical University (JP)
- Aichi Medical University Hospital (JP)
Publication Details
- Journal
- Respiratory Endoscopy
- Published
- 2026-03-26
- DOI
- https://doi.org/10.58585/respend.2025-0060
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00