Anti‐Inflammatory Effects of <i>Stachys pilifera</i> Extracts in LPS‐Stimulated RAW264.7 Macrophages
By downregulating NF-κB activity, S. pilifera Benth. effectively modulates the expression of key proinflammatory mediators, including inducible NO synthase (iNOS) and COX-2, ultimately leading to reduced NO and PGE<sub>2</sub> production. These findings suggest that S. pilifera Benth. may exert its anti-inflammatory effects through inhibition of the NF-κB signaling pathway, offering potential therapeutic applications in the management of chronic inflammatory diseases.
Authors
- Mehdi Fazeli
- Z Salehpour
- Ehsan Barati
Institutions
- Howard University (US)
- Shiraz University (IR)
- Yasuj University of Medical Sciences (IR)
Publication Details
- Journal
- Mediators of Inflammation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/mi/7210911
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00