<i>Delonix regia</i> flower extract protects against diabetic cardiac remodeling via modulating eNOS/NO/cGMP and NF-κB/iNOS/TNF-α trajectories
Methanolic extract of D. regia may have therapeutic potential in the attenuating left ventricular remodeling associated with diabetic cardiomyopathy. These effects appear to be associated with modulation of eNOS/NO/cGMP and NF-κB/iNOS/TNF-α trajectories, along with anti-apoptotic and antifibrotic actions.
Authors
- Maged E. Mohamed (ORCID: https://orcid.org/0000-0002-1216-8703)
- Ahmed S. Abdelkhalek (ORCID: https://orcid.org/0000-0003-2198-0549)
- Islam Mostafa (ORCID: https://orcid.org/0000-0002-6437-5528)
- Noura A. Hassan (ORCID: https://orcid.org/0000-0001-8941-3781)
- Mohamed El-Husseiny El-Sadek
- Heba Osama Mohammed
- Shweta Chhajed (ORCID: https://orcid.org/0000-0003-4234-1113)
- Sixue Chen
- Craig Dufresne
- Nadia Hassan
- Asmaa M Arafa
- Khaled A Al-Zayat
- Hadeer Omar Abdelmoniem
Institutions
- Zagazig University (EG)
- University of Florida (US)
- University of Mississippi (US)
- General Organization For Teaching Hospitals and Institutes (EG)
- Thermo Fisher Scientific (United States) (US)
- King Faisal University (SA)
- Thermo Fisher Scientific (Israel) (IL)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1093/jpp/rgag024
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00