Large-scale protein conformational transitions revealed by weighted ensemble simulations and EPR
Large-amplitude protein conformational changes are essential for cellular processes. Electron paramagnetic resonance (EPR) spectroscopy can detect such conformational changes by measuring distances between site-directed spin labels, but lacks atomistic detail....
Authors
- Xiaowei Bogetti
- Lillian T. Chong (ORCID: https://orcid.org/0000-0002-0590-483X)
- Anthony T. Bogetti (ORCID: https://orcid.org/0000-0003-0610-2879)
- Darian T. Yang (ORCID: https://orcid.org/0000-0002-8654-3529)
- Shramana Palit
- Sunil Saxena
- Olivia Wood
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- Chemical Science
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5sc08971a
- Primary Topic
- Electron Spin Resonance Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00