Liquid biopsy in oral cancer: Detection of TP53 codon 72 polymorphism in saliva
Background: Saliva-based liquid biopsy offers non-invasive genotyping for OSCC. Methods: 33 pre-surgical saliva samples and matched tissue samples. Extracted salivary cell-free DNA; TP53 codon 72 polymorphism (c.215C>G) detected by ddPCR and compared with tissue DNA. Results: Genotypes: C/G 45.5%, G/G 36.3%, C/C 18.2%. Concordance observed between salivary cfDNA and tissue DNA. Conclusion: Saliva is a reliable source for TP53 codon 72 genotyping; supports feasibility of saliva liquid biopsy in OSCC.
Authors
- Audrey Madonna D’Cruz (ORCID: https://orcid.org/0000-0002-1459-591X)
- Gunimala Chakraborty (ORCID: https://orcid.org/0000-0001-5904-492X)
- Anirban Chakraborty (ORCID: https://orcid.org/0000-0003-3476-6576)
- Vinay Kumar J. Rajendra
Institutions
- Nitte University (IN)
- K.S. Hegde Hospital (IN)
Publication Details
- Journal
- Indian Journal of Dental Research
- Published
- 2026-03-01
- DOI
- https://doi.org/10.4103/ijdr_202637s1_abs_60
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00