Body Roundness Index and All‐Cause Mortality in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Dual‐Cohort Study

BRI demonstrates a significant linear association with mortality in the US MASLD population. In the Chinese elderly MASLD population, statistical power was insufficient to draw definitive conclusions about BRI-mortality associations. The observed between-cohort heterogeneity likely reflects multiple factors, including differences in age structure, obesity phenotype, mortality ascertainment methods, and potentially genuine population-specific characteristics. These findings underscore the importance of population-specific validation before extrapolating Western-derived BRI thresholds to Asian populations.

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Publication Details

Journal
Diabetes Obesity and Metabolism
Published
2026-03-26
DOI
https://doi.org/10.1111/dom.70685
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Body Roundness Index and All‐Cause Mortality in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Dual‐Cohort Study

Shishu Yin, Tao Yu, Fuhai Ma, Qi An et al.
Diabetes Obesity and Metabolism
Liver Disease Diagnosis and Treatment
article

Body Roundness Index and All‐Cause Mortality in Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Dual‐Cohort Study

Shishu Yin, Tao Yu, Fuhai Ma, Qi An, Jinxin Shi, G. Zhao, Danian Tang, Tianming Ma, Jian Cui, Xianglong Cao, Zijian Li
article en

Abstract

BRI demonstrates a significant linear association with mortality in the US MASLD population. In the Chinese elderly MASLD population, statistical power was insufficient to draw definitive conclusions about BRI-mortality associations. The observed between-cohort heterogeneity likely reflects multiple factors, including differences in age structure, obesity phenotype, mortality ascertainment methods, and potentially genuine population-specific characteristics. These findings underscore the importance of population-specific validation before extrapolating Western-derived BRI thresholds to Asian populations.

Diabetes Obesity and Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking Union Medical College Hospital (CN)
Good health and well-being
Openalex Percentile: Top 9%
Liver Disease Diagnosis and Treatment
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