CEP170 as a novel molecular link between centrosomal function and cerebral cortical development
Our findings identify CEP170 as a critical regulator of neural progenitor proliferation, neuronal migration, and cortical architecture via centrosome-microtubule interactions, providing new insights into centrosome-linked neurodevelopmental disorders.
Authors
- Yu-Syuan Chang
- Nian-Hsin Chao
- Tzu-Wei Lin (ORCID: https://orcid.org/0000-0001-7022-8316)
- J-F Tsai
- Meng-Han Tsai
- Yu-Ching Liao
- I-Hsuan Lin
- Pei-Shan Hou
- Won-Jing Wang
Institutions
- National Sun Yat-sen University (TW)
- National Yang Ming Chiao Tung University (TW)
- Chang Gung University (TW)
- Taipei Medical University Hospital (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1186/s12929-026-01236-z
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00