Phage therapy of purulent wounds: comparative clinical cytomorphological and microbiological analysis of effectiveness

The principles of purulent wounds treatment in our country are based on the method of active surgical treatment developed in the Department of Wounds and Wound Infections of the Vishnevsky Institute of Surgery (now the Vishnevsky National Research Medical Center of Surgery of the Ministry of Health of the Russian Federation). The results of treatment largely depend on the radicality and thoroughness of the primary surgical debridement of the purulent focus, general and local treatment in the perioperative period. The inclusion of bacteriophages in treatment regimens, especially in combination with local negative pressure, allows for a more pronounced antimicrobial and regenerative effect, which makes this approach promising in the treatment of purulent-inflammatory diseases. The combination of active surgical treatment with local negative pressure therapy and bacteriophage instillation demonstrates pronounced synergy: surgical treatment of purulent wounds reduces microbial contamination and destroys biofilms, which increases the availability of phages. In turn, their bacteriolytic and bacteriostatic activity prevents re-colonization and promotes the transition of the wound process to the regeneration phase, which is especially important in the presence of polyresistance.