A systematic review of adverse effects associated with systemic corticosteroids in the management of leprosy
This systematic review illustrates the range and severity of adverse effects affecting individuals with leprosy who received systemic corticosteroids. Although this review is limited by study heterogeneity, publication bias, and the scarcity of long-term data, it highlights the need for corticosteroid stewardship, structured pharmacovigilance and further research for safer therapeutic alternatives to corticosteroids for leprosy reactions.
Authors
- Stephen L. Walker (ORCID: https://orcid.org/0000-0002-2034-8376)
- Barbara de Barros (ORCID: https://orcid.org/0000-0002-5382-8165)
- Andie I. Lun
Institutions
- Brighton and Sussex Medical School (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Royal Sussex County Hospital (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Hospital for Tropical Diseases (GB)
- University Hospitals Sussex NHS Foundation Trust (GB)
- University College London (GB)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1371/journal.pntd.0014152
- Primary Topic
- Leprosy Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00