Combination of Radiotherapy and Immunotherapy in Advanced Non–Small Cell Lung Cancer
In this cohort study, sequential iRT was associated with longer survival than concurrent iRT in patients with newly diagnosed advanced NSCLC, and chemotherapy was associated with longer survival. In patients with refractory NSCLC who survived at least 90 days, RT with ICI maintenance resulted in nonsignificantly longer survival and an unclear association with chemotherapy. These findings are hypothesis generating and support prospective randomized studies to define optimal sequencing of iRT and use of systemic treatment partners.
Authors
- Abraham Ka Chung Wai (ORCID: https://orcid.org/0000-0001-9984-8156)
- Teddy Tai Loy Lee (ORCID: https://orcid.org/0000-0001-9688-1348)
- Hong Zhou (ORCID: https://orcid.org/0000-0002-3271-6770)
- Can-Bin Fang
- Zhenghao Ye
- Si-Chao Wang
- F. Kong
- Chen Hu
Institutions
- Johns Hopkins University (US)
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Sun Yat-sen Memorial Hospital (CN)
- Prince of Wales Hospital (CN)
- Zhujiang Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Southern Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1001/jamaoncol.2026.0392
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00