Characterisation of the signal to noise ratio of 2-photon microscopes
The signal to noise ratio (SNR) is a key performance metric of an imaging instrument. Here we describe the characterisation of SNR of a custom 2-photon microscope and compare the SNR performance of our microscope with selected commercial 2-photon microscopes. The methodology described in this paper can serve as guidance for others wishing to characterise and benchmark their 2-photon or other point-scanning microscopes.
Institutions
- Nanyang Technological University (SG)
- Singapore Centre for Environmental Life Sciences Engineering (SG)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1038/s41598-026-45224-7
- Primary Topic
- Advanced Fluorescence Microscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00