Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases
We conclude that hyperactive KRAS signaling upregulates MMPs that become excessively activated by the upregulation of the PA pathway. MMPs then degrade the lymphatic valve ECM core, preventing valve formation.
Authors
- K. Li
- Joshua P. Scallan (ORCID: https://orcid.org/0000-0002-1190-7308)
- Luz A. Knauer
- Yuting Fu (ORCID: https://orcid.org/0009-0002-5833-2676)
- Anne Price
- Richa Banerjee (ORCID: https://orcid.org/0000-0002-0183-2779)
- Ying Yang (ORCID: https://orcid.org/0000-0002-8104-5985)
- Diandra M. Mastrogiacomo (ORCID: https://orcid.org/0000-0002-1148-5926)
- George E. Davis (ORCID: https://orcid.org/0000-0002-1549-1610)
- Michael T. Dellinger
Institutions
- University of South Florida (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1161/atvbaha.126.324257
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00