Advances in the Synthesis of Levetiracetam: Classical Approaches and Patented Innovations

Levetiracetam, a widely used antiepileptic drug, is notable for its unique mechanism and favorable safety profile. This review summarizes the evolution of its synthesis, from early methods to recent innovations aimed at improving yield, cost‐efficiency, and environmental impact. Key publications and patents are discussed, highlighting industrial advancements and research progress. The article serves as a valuable resource for professionals in pharmaceutical synthesis and explores future directions in levetiracetam production and related compounds.