Prevalence and Survival Outcomes of L1 Cell Adhesion Molecule–Positive in Endometrial Cancer Across Molecular Subtypes: A Systematic Review and Meta-Analysis
The highest prevalence of L1CAM was found in p53abn endometrial tumors. L1CAM positivity is associated with poor survival outcomes, particularly in MMR-D and NSMP subgroups. These findings highlight the potential of L1CAM as a prognostic biomarker that could refine risk stratification and guide adjuvant management more accurately in endometrial cancer, warranting validation in prospective studies.
Authors
- Sailesh I.S. Kumar (ORCID: https://orcid.org/0000-0003-0832-4811)
- Hiba Siddiqui
- Turkan Aliyeva
Institutions
- Koç University (TR)
- University of Alabama at Birmingham (US)
- Ziauddin Hospital (PK)
Publication Details
- Journal
- JCO Global Oncology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1200/go-25-00519
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00