Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy of Inflammatory Type

Arterial ischemic stroke (AIS) in children is frequently associated with underlying arteriopathy. We report a 13-year-old male with progressive AIS due to focal cerebral arteriopathy of inflammatory type (FCA-i). Despite initial medical therapy-including antiplatelet agents, immunosuppressive therapy, antimicrobial treatment, and intra-arterial spasmolysis-he experienced clinical and radiographic deterioration. Endovascular therapy with balloon angioplasty and fibrin-heparin-coated intracranial stents achieved successful revascularization and stabilization. Vessel wall MRI and elevated <i>Mycoplasma pneumoniae</i> antibodies supported the diagnosis of FCA-i. Follow-up demonstrated sustained stent patency and vascular improvement, with persistent distal upper-extremity-predominant hemiparesis.

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Journal
American Journal of Neuroradiology
Published
2026-03-26
DOI
https://doi.org/10.3174/ajnr.a9317
Primary Topic
Intracranial Aneurysms: Treatment and Complications
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article
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article

Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy of Inflammatory Type

Christian Brickmann, Marija Čagalj, Thomas Witton-Davies, Maximilian Koppers et al.
American Journal of Neuroradiology
Intracranial Aneurysms: Treatment and Complications
article

Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy of Inflammatory Type

Christian Brickmann, Marija Čagalj, Thomas Witton-Davies, Maximilian Koppers, Anastasios Mpotsaris, Anna Schaper
article en

Abstract

Arterial ischemic stroke (AIS) in children is frequently associated with underlying arteriopathy. We report a 13-year-old male with progressive AIS due to focal cerebral arteriopathy of inflammatory type (FCA-i). Despite initial medical therapy-including antiplatelet agents, immunosuppressive therapy, antimicrobial treatment, and intra-arterial spasmolysis-he experienced clinical and radiographic deterioration. Endovascular therapy with balloon angioplasty and fibrin-heparin-coated intracranial stents achieved successful revascularization and stabilization. Vessel wall MRI and elevated <i>Mycoplasma pneumoniae</i> antibodies supported the diagnosis of FCA-i. Follow-up demonstrated sustained stent patency and vascular improvement, with persistent distal upper-extremity-predominant hemiparesis.

American Journal of Neuroradiology
München Klinik (DE)
Openalex Percentile: Top 14%
Intracranial Aneurysms: Treatment and Complications
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Fibrin-Heparin-Coated Intracranial Stents as Salvage Therapy in Pediatric Focal Cerebral Arteriopathy of Inflammatory Type — Christian Brickmann, Marija Čagalj, et al. · American Journal of Neuroradiology (2026) | TGRS Research Map | TGRS