Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

When a phosphoryl oxygen interacts with two H-bond donors, the strength of the second H-bonding interaction much weaker than the first interaction, due to electrostatic repulsion between the two donors.

Authors

Maria Cristina Misuraca (ORCID: https://orcid.org/0000-0001-7024-4535)
Christopher A. Hunter

Institutions

University of Cambridge (GB)

Publication Details

Journal: Chemical Science
Published: 2026-01-01
DOI: https://doi.org/10.1039/d6sc01693f
Primary Topic: Crystallography and molecular interactions
Type: article
Field-Weighted Citation Impact: 0.00

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article

Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

Maria Cristina Misuraca, Christopher A. Hunter

Jan 1, 2026

Chemical Science

Crystallography and molecular interactions

article

Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor

Maria Cristina Misuraca, Christopher A. Hunter

January 1, 2026article en

Abstract

Chemical Science

University of Cambridge (GB)

Openalex Percentile: Top 6%

Crystallography and molecular interactions

DOI Open Access PDF OpenAlex

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Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor — Maria Cristina Misuraca, Christopher A. Hunter · Chemical Science (2026) | TGRS Research Map | TGRS