Four‐Octyl Itaconate Alleviates <i>Enterococcus faecalis</i> ‐Induced Apical Periodontitis by Inhibiting Macrophage <scp>M1</scp> Polarisation
4-OI inhibits E. faecalis-induced macrophage M1 polarisation probably by activating the Nrf2 antioxidant system, thereby suppressing experimental apical periodontitis in mice. These findings suggest that 4-OI possesses great potential as a valuable adjunct to conventional root canal therapy in the management of E. faecalis-related refractory apical periodontitis.
Authors
- Rongyang Ma
- Weidong Zhao (ORCID: https://orcid.org/0000-0002-4444-6595)
- Yuyi Luo
- Zilong Deng (ORCID: https://orcid.org/0000-0002-5873-3595)
- Rui Liang
- Qinyuan Du
- Simin Guo
Institutions
- Guangdong Province Stomatological Hospital (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1111/iej.70152
- Primary Topic
- Endodontics and Root Canal Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00