Pachychoroid pigment epitheliopathy: long-term structural changes and risk factors for disease evolution
PPE demonstrates progressive RPE alterations over time despite stable retinal and choroidal thickness. Greater baseline choroidal thickness and limited initial RPE involvement predict faster lesion expansion, supporting PPE as an active and evolving condition requiring regular multimodal monitoring.
Authors
- Enrico Borrelli (ORCID: https://orcid.org/0000-0003-2815-5031)
- Francesco Petrillo (ORCID: https://orcid.org/0000-0003-0446-2846)
- Pasquale Viggiano (ORCID: https://orcid.org/0000-0002-0323-967X)
- Federica Lo Cascio
- Chiara Olivieri (ORCID: https://orcid.org/0009-0002-5207-264X)
- Francesco Boscia
- Michele Reibaldi
- Paola Marolo
- Gabriele Monici
Institutions
- CTO Hospital (IT)
- Biruni University (TR)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Eye
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1038/s41433-026-04410-7
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00