C16-ceramide modulates sex-dimorphic defense strategies under cold stress in Cherax quadricarinatus via JAK-STAT suppression and oxidative disruption
This study provides the first evidence of sexual dimorphism in JAK-STAT mediated cold adaptation in invertebrates, identifies C16-ceramide as a regulator of sex-specific defense strategies, and confirms the penetration of sexual dimorphism into conserved molecular stress response networks.
Authors
- Xiaojun Xu (ORCID: https://orcid.org/0000-0003-4379-8748)
- Huiyi Cai
- Shuzhi Li
- Bao Lou
- Honglin Chen
Institutions
- Institute of Hydrobiology (CN)
- ZheJiang Academy of Agricultural Sciences (CN)
- China Jiliang University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1186/s13293-026-00892-y
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00