Synthesis, Molecular Docking Study and Biological Activity Evaluation of Some New Heterocyclic Compounds

The current study aimed to synthesize a new series of heterocyclic compounds by reacting Schiff bases with various compounds and then evaluating them in vitro as antimicrobial and anticancer agents. Antimicrobial activity was tested against Escherichia coli and Staphylococcus aureus bacteria, the results showed that some of these compounds have good activity in comparison to Amoxicillin. Cytotoxicity assays were performed on the lung cancer cell lines (A549), some of the tested compounds showed encouraging cytotoxic effects at 500 μM with good IC50 values. Furthermore, a molecular docking study showed that some of the new derivatives exhibited high selectivity toward c-Met tyrosine kinase protein receptors with better binding energy compared with Amoxicillin. The physical properties of the prepared compounds were obtained and they were studied spectroscopically using FT-IR, 1H NMR and 13C NMR spectroscopy.