Whole-genome CRISPR screening identifies genetic modifiers of stem cell–derived islet transplantation
In conclusion, this study demonstrats improved glucose regulation at a subcutaneous transplant site. In addition, we show that FCAMR SC-islets could play a role in systemic metabolism when transplanted into the kidney capsule or hindleg muscle. Overall, our study establishes a functional screening approach to identify gene candidates to improve SC-islet transplantation.
Authors
- Matthew Ishahak (ORCID: https://orcid.org/0000-0002-7494-6048)
- Noyonika Mukherjee (ORCID: https://orcid.org/0000-0001-6692-3631)
- Mira Shunkarova
- Marlie M. Maestas (ORCID: https://orcid.org/0000-0003-4396-9770)
- Kameron Bradley
- Jeffrey R Millman
- James Lu
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1093/stcltm/szag012
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00