Intravitreal Bevacizumab plus Methotrexate for iris and ciliary body metastasis from lung cancer
To describe a case of iris and ciliary body metastasis from lung adenocarcinoma responding to intravitreal bevacizumab and methotrexate. A 66-year-old man presented with an amelanotic vascular lesion of the iris and ciliary body (7 × 4 mm, 4 mm thick). Fine-needle aspiration biopsy confirmed lung adenocarcinoma. After intravitreal bevacizumab and methotrexate, the tumor showed marked regression within 2 months. Intravitreal bevacizumab combined with methotrexate may represent a minimally invasive alternative to radiation therapy for ocular metastases.
Authors
- M. S. P. A. Folgosa
- Igor Neves Coelho (ORCID: https://orcid.org/0000-0001-9987-6886)
- Thaís Bastos (ORCID: https://orcid.org/0000-0002-4096-8724)
- Zélia M. Corrêa (ORCID: https://orcid.org/0000-0003-2946-3757)
- Letícia Oliveira Audi
- Fernando Chahud
- Rodrigo Jorge
Institutions
- Universidade de Ribeirão Preto (BR)
- Universidade de São Paulo (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- American Journal of Ophthalmology Case Reports
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.ajoc.2026.102571
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00