Smad7 Downregulation Promotes Ferroptosis in Pulmonary Arterial Hypertension via the TGF-β1–Smad2/3 Pathway
This study provides preliminary evidence that SMAD7 may negatively regulate ferroptosis via the TGF-β1-Smad2/3 Pathway in pulmonary artery endothelial cells and thereby contribute to pulmonary vascular remodeling in PAH. These findings highlight SMAD7 as a potential therapeutic target for PAH.
Authors
- Xiaolan Chen
- Wenteng Wu
- Huan Liu (ORCID: https://orcid.org/0000-0002-0253-647X)
- Xueying Wang (ORCID: https://orcid.org/0000-0001-6445-8887)
- Wenhui Huang (ORCID: https://orcid.org/0000-0001-8123-2441)
- Kun Yu (ORCID: https://orcid.org/0009-0004-5623-6431)
- Hui Zhang
- Yue Wang
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Shock
- Published
- 2026-03-26
- DOI
- https://doi.org/10.1097/shk.0000000000002832
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00