Targeting EGFR in glioblastoma: lessons from a disappointing journey. A systematic review
EGFR-focused TKIs were largely disappointing as a treatment for GBM. Longstanding issues, including treatment resistance, tumor heterogeneity, and blood-brain barrier penetration persist. Future efforts must focus on tackling these issues, and prioritizing patient selection via biomarkers.
Authors
- Ronald Moussa
- Ahmad Assi (ORCID: https://orcid.org/0009-0008-2367-8275)
- Ali Berro
- Sarah Samhat
- Yara Gebran
- Grace SABRA
- Rita HADDAD
Institutions
- Hôtel-Dieu de France (LB)
Publication Details
- Journal
- Journal of Neurosurgical Sciences
- Published
- 2026-03-01
- DOI
- https://doi.org/10.23736/s0390-5616.26.06708-1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00