Mendelian randomization implicates circulating plasma proteins in gout risk and identifies candidate therapeutic targets
This exploratory, assumption-dependent MR work nominates five circulating proteins as hypothesis-generating candidates for gout risk and potential therapeutic targeting. Given method assumptions and cross-dataset heterogeneity, functional validation and independent replication are required to clarify mechanisms, confirm targetability, and assess translational relevance.
Authors
- Yu Shrike Zhang (ORCID: https://orcid.org/0000-0002-0045-0808)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Gui-Hai Chen (ORCID: https://orcid.org/0009-0007-7471-737X)
- Tao Yu (ORCID: https://orcid.org/0009-0003-3518-1411)
- Yongtao Zhang (ORCID: https://orcid.org/0000-0002-7809-5631)
- Tianrui Wang
- Zixian Dang
- Pixue Yu
- Zhen Shang
Institutions
- Qingdao University (CN)
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Xian Central Hospital (CN)
- Weifang People's Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Qingdao Eighth People's Hospital (CN)
Publication Details
- Journal
- International Journal of Immunopathology and Pharmacology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1177/03946320261428859
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00