Regulation of Inflammatory Responses and Apoptosis: sgp130fc as a Potential Therapeutic Agent for Sepsis-Associated Kidney Injury
sgp130Fc confers renoprotective effects in a murine model of sepsis by selectively targeting the IL-6 trans-signaling pathway and modulating STAT3/NF-κB signaling to inhibit inflammation and apoptosis. These findings highlight the therapeutic potential of sgp130Fc in SAKI and support further clinical investigation.
Authors
- Zhenjie Hu
- Ye Chen (ORCID: https://orcid.org/0000-0002-7964-7899)
- Xuefang Liu
- Pan Zhou
- Congcong Zhao
- Ya Liu
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Fourth Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Shock
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1097/shk.0000000000002843
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00