The correlation between serum resistin level and iron status in patients with type 2 diabetes mellitus with chronic kidney disease

Context In Egypt 42% of diabetics have nephropathy. The link of diabetes mellitus (DM), diabetic nephropathy, and iron deficiency is clarified through mechanism of low-grade chronic inflammation. Resistin being one of the revered bioactive adipokines recently being implicated in inflammatory processes so it is privilege to explore its correlation with iron status. Aims Elucidate the correlation between serum resistin and iron status in type 2 DM with chronic kidney disease (CKD). Settings and design Cross-sectional study. Patients and methods Study included 150 patients were subdivided into three groups, each group 50; group I type 2 DM with normal estimated glomerular filtration rate (eGFR), group II type 2 DM (e-GFR<60 ml/min/1.73 m 2 for ≥3 months) and not on hemodialysis, group III: type 2 DM (e-GFR<15 ml/min/1.73 m 2 ) on hemodialysis. Serum resistin, serum ferritin, serum iron, serum total iron binding capacity, saturation of transferrin, C-reactive protein were done. Statistical analysis used Utilizing IBM-SPSS 24.0. Results Serum resistin shows, highly significant level in group (III) more than group (II) and (I) respectively ( P 1, 2<0.001) ( P 3=0.004), and shows highly significant negative correlation with hemoglobin, (iron, and transferrin saturation). ( P 1 and P 3<0.001) for iron, ( P =0.017), ( P =0.008) ( P <0.001) for transferrin saturation and ( P =0.007), ( P =0.005), ( P <0.001) for Hb. While shows positive correlation with serum ferritin ( P =0.021), ( P =0.012) and ( P <0.001). Cut-off value of serum resistin (3000) for type 2 DM with CKD and iron deficiency. Conclusion Resistin correlation of iron regulatory pathways with inflammatory conditions being a novel biomarker will aids in early prediction, better control of mischievous effects of prevalent worldwide diseases as DM with cut-off value of serum resistin level (3000 pg/ml) for type 2 DM with CKD and iron deficiency.