Molecular epidemiology and clinical differentiation between <i>Clostridioides difficile</i> infection and colonization across three chicago medical centers
Abstract In a retrospective cohort study at three Chicago academic medical centers, 22/81 (27.2%) patients with a clinically adjudicated positive C. difficile test result were colonized. Recent antibiotic usage predicted true infection (adjusted odds ratio: 4.38 for infection). Restriction endonuclease analysis(REA) group Y (29.3%) replaced BI (9.3%) as the dominant strain.
Authors
- Adam Cheknis
- Kathleen G. Beavis (ORCID: https://orcid.org/0000-0002-5611-6809)
- Andrew M Skinner (ORCID: https://orcid.org/0000-0001-9452-9316)
- Youngchang Kim (ORCID: https://orcid.org/0000-0002-1610-4889)
- Vera Tešić (ORCID: https://orcid.org/0000-0003-0004-8445)
- Charlesnika Evans
- Stuart Johnson
- Larry K. Kociolek
- Dale N. Gerding
- Mary K. Hayden
- Nicholas M. Moore
- Amanda Harrington
- Michael Lin
Institutions
- Rush University Medical Center (US)
- Lurie Children's Hospital (US)
- Loyola University Medical Center (US)
- University of Utah (US)
- Edward Hines, Jr. VA Hospital (US)
- University of Chicago (US)
- VA Salt Lake City Healthcare System (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1017/ash.2026.10306
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00