Vaccinia virus armed with IL-21 can cure murine colorectal cancer liver metastases via intravenous administration
VVLΔTK-STCΔN1L-mIL21 can effectively reach liver metastases via tail vein injection and exert potent antitumor effects, significantly extending the survival of mice.
Authors
- Z. Zhang
- Yijia He
- Ruixian Liu (ORCID: https://orcid.org/0000-0002-3065-6743)
- Hui Zhang (ORCID: https://orcid.org/0009-0008-1937-9387)
- Yan Liu (ORCID: https://orcid.org/0009-0007-6047-7299)
- Shiyang Ning
- Yaohe Wang
- Louisa S Chard Dunmall
- Yangyang Jia
- Yimeng Xia
- Na Wang
- Junzhi Yu
Institutions
- Queen Mary University of London (GB)
- Zhengzhou University (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-012479
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00