Executive Summary of the American Radium Society® (ARS) Appropriate Use Criteria (AUC) for Selective Use of Pelvic Radiotherapy in Locally-Advanced Rectal Cancer: A Consensus Statement

Of the 110 articles identified using the search strategy, 35 were selected that met all inclusion criteria. Of the 35 references used as evidence, 35 are categorized as therapeutic including 14 well-designed studies (Phase II randomized and Phase III), 12 moderately well-designed studies that account for most common biases (matched cohort and Phase II studies), 7 studies with design limitations (retrospective reviews), and 3 meta-analyses. Variant cases were developed as examples to illustrate practical applications of consensus recommendations for when RT can be safely omitted. A treatment algorithm is also provided to assist with treatment decisions when considering selective use of pelvic RT.

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Publication Details

Journal
International Journal of Radiation Oncology*Biology*Physics
Published
2026-03-01
DOI
https://doi.org/10.1016/j.ijrobp.2026.03.033
Primary Topic
Colorectal and Anal Carcinomas
Type
article
Field-Weighted Citation Impact
0.00
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article

Executive Summary of the American Radium Society® (ARS) Appropriate Use Criteria (AUC) for Selective Use of Pelvic Radiotherapy in Locally-Advanced Rectal Cancer: A Consensus Statement

Timothy E. Kennedy, Suzanne Russo, Christopher J. Anker, Eric David Miller et al.
International Journal of Radiation Oncology*Biology*Physics
Colorectal and Anal Carcinomas
article

Executive Summary of the American Radium Society® (ARS) Appropriate Use Criteria (AUC) for Selective Use of Pelvic Radiotherapy in Locally-Advanced Rectal Cancer: A Consensus Statement

Timothy E. Kennedy, Suzanne Russo, Christopher J. Anker, Eric David Miller, Eric J Dozios, Gerard Abood, Navesh Sharma, Joseph Attallah, Dmitriy Akselrod, Krishan R. Jethwa, Neil B. Newman, Diane C. Ling, Zhaohui Jin, Gwen Wilson, Christopher L. Hallemeier, D. Chamil Codipilly, Percy Lee, William Small, Leila Tchelebi
article en

Abstract

Of the 110 articles identified using the search strategy, 35 were selected that met all inclusion criteria. Of the 35 references used as evidence, 35 are categorized as therapeutic including 14 well-designed studies (Phase II randomized and Phase III), 12 moderately well-designed studies that account for most common biases (matched cohort and Phase II studies), 7 studies with design limitations (retrospective reviews), and 3 meta-analyses. Variant cases were developed as examples to illustrate practical applications of consensus recommendations for when RT can be safely omitted. A treatment algorithm is also provided to assist with treatment decisions when considering selective use of pelvic RT.

International Journal of Radiation Oncology*Biology*Physics
University of Vermont (US), University of Southern California (US), City Of Hope National Medical Center (US), Mayo Clinic (US), University of Miami (US), Georgetown University (US), Loyola University Chicago (US), The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US), WinnMed (US), Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US), WellSpan Health (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US), MetroHealth Medical Center (US), The Ohio State University (US)
Good health and well-being
Openalex Percentile: Top 8%
Colorectal and Anal Carcinomas
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