Targeting <i>SPP1</i> <sup>+</sup> TAMs associated with liver metastasis reverses immunosuppression and synergizes with immunotherapy in colorectal cancer
This study delineates the spatial, developmental, and metabolic heterogeneity of <i>SPP1</i> <sup>+</sup>TAMs in CRC, identifying <i>SPP1</i> <sup>+</sup>TAMs as key mediators of immunosuppression and metastasis. Targeting these populations with combination therapy effectively enhances antitumor immunity, presenting a novel translational strategy for CRC immunotherapy.
Authors
- Lei Zhao (ORCID: https://orcid.org/0000-0003-1263-1742)
- YiLin Lin
- Sai Zhao (ORCID: https://orcid.org/0000-0001-9362-6835)
- Zhanlong Shen
- Z. K. Chen
- Mingxuan Zhu
- Shan Wang
- Changjiang Yang
- Yingjiang Ye
Institutions
- Fujian Medical University (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Mengchao Hepatobiliary Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1136/jitc-2025-014128
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00