Iridium(III)‐Catalyzed C–H Amidation With <i>N</i> ‑Methoxyamide as an Amidation Reagent
The iridium-catalyzed C-H amidation of two classes of arenes was developed, using N-methoxybenzamide as the amidating agent via N─O bond cleavage to form metal-nitrenoid intermediates. This transformation proceeds with precise site selectivity, mild conditions, and high yields, offering a practical and complementary approach to existing amide synthesis protocols.
Authors
- Miaomiao Tian (ORCID: https://orcid.org/0000-0002-4947-1685)
- Panjie Hu (ORCID: https://orcid.org/0000-0002-3778-7914)
- Cancan Feng
- Jinlei Wang (ORCID: https://orcid.org/0000-0002-5586-5349)
- Bingxian Liu
- Lele Yu
Institutions
- Zhoukou Normal University (CN)
- Henan Normal University (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1002/asia.70707
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00