<scp>LILRB1</scp> Is a Prognostic‐Related Biomarker Correlated With Immune Infiltration in Head–Neck Squamous Cell Carcinoma
Collectively, high LILRB1 expression in HNSCC was accompanied by the infiltration of various immune effector cells. LILRB1 may shape the tumor microenvironment of HNSCC, mediating the interactions between cancer cells and macrophages, as well as between cancer cells and CD8+ T cells, via the SPP1-CD44 and CXCL13-CXCR5 axes. Our findings illustrate that LILRB1 serves as a prognostic-related biomarker associated with immune infiltration in HNSCC.
Authors
- Juli J. Lin
- Qiong Wu (ORCID: https://orcid.org/0000-0003-1488-038X)
- Ye Zhou (ORCID: https://orcid.org/0000-0002-8780-0099)
- Shuo Gu (ORCID: https://orcid.org/0000-0001-9054-1676)
- Xianyang Luo (ORCID: https://orcid.org/0000-0003-1542-6832)
- Bing Zhang (ORCID: https://orcid.org/0000-0002-9725-2524)
- Junhua Wu
- Zhicong Hong
- Shuai Chen
- Jingjing He
- Jing He
- Mingquan Cai
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Children’s Hospital of Fudan University Xiamen Branch (CN)
- Xiamen Maternal and Child Health Hospital (CN)
- Shenyang University (CN)
- Xiamen University of Technology (CN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1002/cam4.71727
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00