Recent Developments and Applications of Capillary and Microchip Electrophoresis in Proteomics and Peptidomics (2023–2025)

This review article presents a broad overview of developments and applications of capillary electrophoresis (CE) and microchip electrophoresis (MCE) in peptidomics and proteomics in the period 2023-2025. It deals with various methodological aspects, such as sample preparation including preseparation and preconcentration, multidimensional separations by on-line or off-line coupled different CE, MCE, and LC techniques, and their hyphenation with MS detection. Innovations in bottom-up and top-down proteomics are reported. Furthermore, application of CE and MCE techniques in various peptidomic and proteomic studies are demonstrated. They embrace monitoring of posttranslational modifications, basic biological and biochemical research, and analysis of clinical and food samples.