Filgotinib treatment modulates frequency and gene expression of circulating immune cell subsets in ulcerative colitis
Filgotinib response was associated with normalization of the cellular frequency and gene expression levels of B cells and phagocytic mononuclear cells in UC patients, resulting in immune profiles resembling those of healthy controls.
Authors
- Angie Hertz
- Andrew N. Billin (ORCID: https://orcid.org/0000-0001-7752-0934)
- Donna Shows (ORCID: https://orcid.org/0000-0002-2792-3839)
- Yan Liang (ORCID: https://orcid.org/0000-0002-6972-2541)
- Grace Park
- Emily Wendt
- Vladislav A. Malkov
- Duncan Hindmarch
- James D Lord
- Ramya Kongala
Institutions
- Washington Research Foundation (US)
- Gilead Sciences (United States) (US)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1093/ecco-jcc/jjag028
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00