Impact of Obesity-Related Cerebral Iron Overload and Perfusion Alterations on Cognition: A Multi-parametric MRI Study
This study suggests that obese patients may exhibit iron deposition and perfusion abnormalities in certain areas of the brain. Bilateral red nuclei iron deposition is closely related to cognitive impairment. The multimodal combined application of QSM and ASL provides imaging evidence for revealing the impact of obesity on brain structure and function, and also provides potential biomarkers for targeted interventions in the future.
Authors
- Fenyang Chen
- Qingqing Wen
- Xueji Zhang (ORCID: https://orcid.org/0000-0002-0035-3821)
- Zhongxiang Ding
- Manqing Yu
- YaFei Zheng
- Yihan Suo
- Xuewei Tang
- Zhiliang Zhang
- Huan Chen
Institutions
- Zhejiang Chinese Medical University (CN)
- General Electric (Spain) (ES)
- United States Air Force (US)
- Zhejiang Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Behavioural Brain Research
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.bbr.2026.116186
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00