Silencing RPL9 promotes malignant proliferation in breast cancer cells

We identified and constructed a 9-RBP based scoring model and a clinical prognostic nomogram for accurately predicting the survival probability and assessing the tumor microenvironment of patients with BRCA. Moreover, our findings firstly demonstrated that RPL9 downregulation correlated with poor clinical outcomes and functionally drives tumor cell proliferation, establishing it as a potential therapeutic target and prognostic biomarker for BRCA.

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Publication Details

Journal
International Journal of Immunopathology and Pharmacology
Published
2026-03-01
DOI
https://doi.org/10.1177/03946320261422055
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Silencing RPL9 promotes malignant proliferation in breast cancer cells

Yuxuan Song, Junze Dai, R. Liu, Xudong Zhu et al.
International Journal of Immunopathology and Pharmacology
Ferroptosis and cancer prognosis
article

Silencing RPL9 promotes malignant proliferation in breast cancer cells

Yuxuan Song, Junze Dai, R. Liu, Xudong Zhu, Heng Zhang, Xin Wang, Yefu Liu, Tong Zhu, Dingye Zhang, Wenxin Li, Hailin Tang, Zhaohu Shi
article en

Abstract

We identified and constructed a 9-RBP based scoring model and a clinical prognostic nomogram for accurately predicting the survival probability and assessing the tumor microenvironment of patients with BRCA. Moreover, our findings firstly demonstrated that RPL9 downregulation correlated with poor clinical outcomes and functionally drives tumor cell proliferation, establishing it as a potential therapeutic target and prognostic biomarker for BRCA.

International Journal of Immunopathology and PharmacologyVol. 40
Sun Yat-sen University (CN), Dalian Medical University (CN), Sun Yat-sen University Cancer Center (CN), Jiangjin Central Hospital (CN), Liaoning Cancer Hospital & Institute (CN), China Medical University (CN)
Good health and well-being
Openalex Percentile: Top 9%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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Silencing RPL9 promotes malignant proliferation in breast cancer cells — Yuxuan Song, Junze Dai, et al. · International Journal of Immunopathology and Pharmacology (2026) | TGRS Research Map | TGRS