Colon-restricted Pten haploinsufficiency models PI3K pathway-driven invasion in colorectal cancer
The effect of Pten haploinsufficiency on colonic tumor formation in mice reaffirms the significance of PI3K alterations in tumor evolution in human colorectal cancers.
Authors
- Hirotaka Tashiro (ORCID: https://orcid.org/0000-0003-2615-8183)
- Hikaru Nakahara (ORCID: https://orcid.org/0000-0003-2540-707X)
- Yusuke Sotomaru (ORCID: https://orcid.org/0000-0002-2856-1518)
- Haruki Sada
- Yuji Urabe
- Takao Hinoi
- Eric R. Fearon
- Hideki Ohdan
- Hiroaki Niitsu
- Masatoshi Kochi
- Naoya Sakamoto
- Shiro Oka
Institutions
- Hiroshima University (JP)
- University of Michigan (US)
- Michigan Medicine (US)
- Hiroshima University Hospital (JP)
- Higashihiroshima Medical Center (JP)
- National Cancer Center Hospital East (JP)
- Kure Medical Center (JP)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2026-03-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2026.101773
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00