Safety and Feasibility of Transcatheter Aortic Valve Replacement in Patients With Hematologic Neoplasms

For patients with severe, symptomatic aortic stenosis (AS) who are poor surgical candidates, transcatheter aortic valve replacement (TAVR) offers a less invasive alternative to surgical valve replacement. Patients with hematologic neoplasms and severe AS are a high-risk subset, with increased risk of bleeding and infection, who have historically been excluded from clinical investigation in TAVR. Prior case reports have demonstrated successful TAVR in patients with hematologic neoplasms; however, there remains minimal literature on TAVR in this population. We present a series of 10 patients with hematologic neoplasms who underwent successful TAVR. Our cohort experienced minimal periprocedural complications and demonstrated marked improvement in cardiovascular function, with few long-term cardiac complications and favorable survival at 1 year post-procedure. These findings suggest that TAVR may be a feasible therapy in patients with concomitant hematologic neoplasms and severe, symptomatic AS.