The HONEST Cohort Study

The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to reduce complications associated with transvenous leads while preserving efficacy in terminating malignant ventricular arrhythmias. However, current evidence supporting the S-ICD is primarily derived from industry-sponsored studies and highly specialized centers. This study aims to offer a comprehensive, nationwide, real-world assessment of all patients who underwent S-ICD implantation in France. The HONEST (coHOrte fraNcaise des dEfibrillateurs Sous cuTanés) cohort is a French nationwide, single-arm, observational ongoing study that enrolled all patients who underwent implantation of an S-ICD (EMBLEM, Boston Scientific) between October 2012 (the first implantation in France) and December 2019. Clinical endpoints are centrally adjudicated. Overall, 4,924 (77% males; 49.9 years) patients, representing 98.2% of all S-ICD implantations during the study period in France, were included. The HONEST study represents the first nationwide cohort evaluating S-ICD recipients to provide contemporary, real-world data. Its goal is to identify areas for improvement and refine strategies to prevent sudden cardiac death. (S-ICD French Cohort Study [HONEST]; NCT05302115)

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Journal
JACC Advances
Published
2026-03-01
DOI
https://doi.org/10.1016/j.jacadv.2026.102604
Primary Topic
Insurance, Mortality, Demography, Risk Management
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article
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article

The HONEST Cohort Study

Philippe Poret, Éloi Marijon, François Wiart, Jérôme Horvilleur et al.
JACC Advances
Insurance, Mortality, Demography, Risk Management
article

The HONEST Cohort Study

Philippe Poret, Éloi Marijon, François Wiart, Jérôme Horvilleur, Lila Khris, Nicolas Luconi, Y. Dagher Hayeck, Guillaume Kabalu, Lionel Ovart, Raphael Castro Martins, Edouard Siméon, C. Duplantier, P. Le Franc, Didier Scarlatti, Guillaume Serzian, P Gaillard, Frederic Ortuno, Nicolas Mignot, Karine Bauley, Isabelle Lecardonnel, Nicolas Clémenty, V. Abdou, Ardalan Sharifzadehgan, A. Hebrard, Raphael Sandras, Claire Vanesson, Sana Sioua, Jérôme Lacotte, Géraldine Bertaux, Yannick Saludas, Sandrine Bellmont, Karim Bel Hadj, P. Houriez, Christèle Cardin, Philippe Jarnier, Marion Pouche, Audrey Lefoulon, François Jourda, Jerome L. Schwartz, W. Amara, Marc Poueymidanette, Romain Sellier, Arnaud Pellissier, Olivier Barthez, S Schiau, Emilie Bastard, Sophie Pynn, Séverine Philibert, Mouna Ben Kilani, Florian Baptiste, Émilie E. Varlet, F. Tréguer, Denis Raguin, Xavier Copie, Baptiste Maille, Gilles Macaluso, Adrien Carabelli, Frédérique Mizon-Gérard, Alexandre Schatz, Hugues Bader, Lilian Marty, Franck Halimi, Gabriel Latcu, J. Ollitrault, Cyril Goujeau, Laurent Liprandi, JEAN BAPTISTE GOURRAUD, Philippe Durand, Stéphane Dennetière, C. Giraudeau, Georges Nadji, Hugues Blangy, Pierre Khattar, B. Godin, F. Philippot, Thibault Villemin, Laurent Fauchier, Rodrigue Garcia, X Dreyfus, F. Monsel, Christine Virbel Alonso, Dominique Pavin, Sandrine Venier, Jonathan Lacaze Gadonneix, M. Lerecouvreux, Sylvain Bodi, Sophie Le Page, Adlane Zemmoura, Thierry Zerah, Samir Fareh, Soraya Anys, Laure Champ-Rigot, Hugues Zimmermann, Jérôme Thévenin, Pénélope Pujadas, Mathieu Courtheix, I. Lagrenade, Michel Voglimacci, Andréas Müssigbrodt, Julien Rischard, Samuel Chauveau, Hugo Brahic, Chrystelle Akret, F. Elmkies, Dominique Celse, Baptiste Favoulet, Antoine Andorin, Pierre Baudinaud, Benoit Guy Moyat, Laurent Fiorina, Christophe Juin, Damien Minois, Olivier Axler, Henri Broustet, Nawale Hajjaji, P Rumeau, Jean-Baptiste Guichard, Denis Gaty, Ahmed Bouharaoua, Lara Dabiri, Alain Lebon, Aymeric Menet, Alaa Al Amoura, Arnaud Bisson, Vincent Mansourati, Dominique Bleinc, Ronan Le Bouar, R. Fouché, Olivier Villejoubert, G Cellarier, Pascal Chavernac, Pierre Lantelme, Edouard Gitenay, P Gallay, Aude Zanutto, Mohanad Mahfoud, Rim El Bouazzaoui, Didier Irles, Sébastien Prévôt, Thibault Hus, Ziad Khoueiry, Sorin Pripon, Marie Fichot, Pamela Damiano, Sarah Traullé, Bruno Ulmer, M Merheb, Stéphane Mourot, Mohamed Belhameche, Jean Faugier, Folco Frattini, Fabrice Demonière, Olivier Garrier, Raoul Bacquelin, Aurélie Guiot, Fawzi Kerkouri, Madeline Espinosa, Arnaud Olivier, A. Messali, Arthur Vaksmann, Sophie Gomes, Thien-Tri Cung, N. Auquier, F. Cransac, Mathieu Amelot, Marie Sadron Blaye-Felice, Fiorella Salerno, Mina Ait Saïd, A. Doucy, Pierre-Yves Zinzius, Mohammed Benkaci Ali, Inamo Jocelyn, Frédéric Victor, P Winum, J S Hermida, François Xavier Hager, Stéphane Evain, M. Chatel, Thomas Chastre, Benjamin Monteil, Hervé Gorka, Christophe Loose, Laura Forelle, Arnaud Savouré, J P Chabert, Cécile Romeyer-Bouchard, Mickael Peyrol, Christian Demasles, Yves Guyomard, Emilie Marcant, Segolene Rouffiac-Noel, Guillaume Galidie, Khadidja Belkir, Aziz Kneizeh, Eric Ramiaramanana, Sebastien Bufflerin, Alexis Durand Dubief, Raphael Gdalia, Abdelhamid Benounane, Bertrand PIERRE, Mathieu Montoy, Antoine Milhem, Jean Claude Deharo, Mathieu Garnier, Antoine Roux, Saida Cheggour, Maxime De Guillebon, Aurélien Miralles, Nicolas Derval, Jean Christophe Amirault, Pierre Frey, Frédéric Sacher, Denis Amet, Vincent Probst, Frederic Anselme, Clement Bars, Michel Chauvin, Damien Bonnet, Daniel Beurrier, Nicolas Hugues, Eric Verbrugge, Yamina Mouhoub, Antoine Da Costa, Jerome Bouet, Alexandre Zhao, Fanny Bouchinet, Francis Bessiere, Vincent Algalarrondo, Olivier Brimont, Julien Pineau, Maciej Kubala, Pierre Sultan, Cyril Zakine, Christophe Leclercq, Arnaud Lazarus, Vincent Galand, Jean Luc Pasquié, Raphaël Demoulin, Gabriel Laurent, Marc Mielczarek, Charles Guenancia, Laurentiu Dorian Nitu, Philippe Couderc, Fabrice Extramiana, Olivier Billon, Estelle Gandjbakhch, Hassan Barake, Bruno Maillier, Victor Waldmann, Julien Seitz, Warda Aoudjeghout, Essia Lakhal-Ben Larbi, Nicolas Sadoul, Géraldine Vedrenne, Pierre Jorrot, Cathy Bertrand, Philippe Maury, Christophe Laure, Antoine Dompnier, Pierre Ollitrault, Nicolas Badenco, Frederic Jean, François Le Gal, Olivier Piot, Cyril Durand, Akli Otmani, Mathieu Becker, Pauline Pinon, Nicolas Lellouche, Monteau Jacques, Lucien Diene, Xavier Jouven, Didier Klug, Philippe Lagrange, Francois Lesaffre, Salem Younsi, Jérôme Hourdain, Cyrus Moini, Jérémie Barraud, Pierre Bordachar, Ghassan Moubarak, Stéphane Combes, Maxime Pons, Pierre Mondoly, Peggy Jacon, Julien Laborderie, Romain Eschalier, Maria Moldovan, Alexis Hermida, Marc Badoz, Arnaud Dulac, Corentin Chaumont, Julien Bertrand, Isabelle Heurtebise, Jean-Paul Albenque, Guillaume Duthoit, Nicolas Klotz, Nathalie Behar, Thomas Lavergne, David Perrot, Vladimir Manenti, Fabien Squara, Benjamin Gal, Alexis Mechulan, Cédric Nguyen, Vincent Ahfat, Sylvain Ploux, Mathieu Steinbach, Vincent Kanczuga, Michael Attali, Jean Litalien, Tej Chalbia, Charlotte Potelle, Bruno Degand, Jacques Levy, Pascal Defaye, Mikael Laredo, Laurence Jesel-Morel, Xavier Waintraub, Jerome Taieb, Romain Cassagneau, Alice Maltret, Antoine Leenhardt, Anne Quentin, Paul-Ursmar Milliez, Radu Moisei, Jean-Marc Dupuis, Kevin Gardey, Christian De Chillou, Olivier Cesari, Daniel Gras, René Gabriel Huguet, Philippe Chevalier, Serge Boveda, Eric Rendu, Julien Roux, Grégoire Massoullié, Garret Gauthier, Olivier Geoffroy, Luc Petit, Bogdan Enache, Jacques Mansourati, Guillaume Domain, Olivier Thomas, Abdeslam Bouzeman, Christelle Marquié, Hervé Poty, Nicolas Combes, Audrey Sagnard, Sok-Sithikun Bun, Philippe Ricard, Luc Freysz, Gael Clerici, Paul Charles, Nathalie Elbaz, Popescu Elena, Corina Moldovan
article en

Abstract

The subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to reduce complications associated with transvenous leads while preserving efficacy in terminating malignant ventricular arrhythmias. However, current evidence supporting the S-ICD is primarily derived from industry-sponsored studies and highly specialized centers. This study aims to offer a comprehensive, nationwide, real-world assessment of all patients who underwent S-ICD implantation in France. The HONEST (coHOrte fraNcaise des dEfibrillateurs Sous cuTanés) cohort is a French nationwide, single-arm, observational ongoing study that enrolled all patients who underwent implantation of an S-ICD (EMBLEM, Boston Scientific) between October 2012 (the first implantation in France) and December 2019. Clinical endpoints are centrally adjudicated. Overall, 4,924 (77% males; 49.9 years) patients, representing 98.2% of all S-ICD implantations during the study period in France, were included. The HONEST study represents the first nationwide cohort evaluating S-ICD recipients to provide contemporary, real-world data. Its goal is to identify areas for improvement and refine strategies to prevent sudden cardiac death. (S-ICD French Cohort Study [HONEST]; NCT05302115)

JACC AdvancesVol. 5(3)
Inserm (FR), École nationale d'ingénieurs de Brest (FR), Université Paris Cité (FR), Centre Hospitalier Universitaire de Grenoble (FR), Centre Hospitalier Universitaire de Nantes (FR), Université de Poitiers (FR), Sorbonne Paris Cité (FR), Centre Hospitalier Régional et Universitaire de Nancy (FR), Hôpital Européen Georges-Pompidou (FR), Centre Hospitalier Universitaire de Poitiers (FR), Laboratoire des Sciences et Techniques de l’Information de la Communication et de la Connaissance (FR), Paris Cardiovascular Research Center (FR), Centre Hospitalier Régional Universitaire de Brest (FR), Interuniversity Institute for High Energies (BE), Clinique Pasteur (FR), Centre Hospitalier Universitaire de Rennes (FR), Hôpital de la Timone (FR), Université de Rouen Normandie (FR), Université Grenoble Alpes (FR)
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