Quantitative relative reflectivity features based on OCT for predicting the efficacy of anti-VEGF therapy in Diabetic Macular Edema at 3 months

Quantitative OCT-derived RR features, especially those reflecting intraretinal cyst characteristics, are strongly associated with short-term anti-VEGF response in DME. ML models incorporating these features may support individualized treatment assessment, with simpler models offering advantages in robustness and interpretability.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2026-03-01
DOI
https://doi.org/10.1016/j.pdpdt.2026.105445
Primary Topic
Retinal Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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OCT
article

Quantitative relative reflectivity features based on OCT for predicting the efficacy of anti-VEGF therapy in Diabetic Macular Edema at 3 months

Guanghua Zhou, Qiaowei Wu, Luonan Qiu, Jingyue Deng et al.
Photodiagnosis and Photodynamic Therapy
Retinal Diseases and Treatments
article

Quantitative relative reflectivity features based on OCT for predicting the efficacy of anti-VEGF therapy in Diabetic Macular Edema at 3 months

Guanghua Zhou, Qiaowei Wu, Luonan Qiu, Jingyue Deng, Xiaolin Yan, Xiaoshan Lin, Honghua Yu
article en

Abstract

Quantitative OCT-derived RR features, especially those reflecting intraretinal cyst characteristics, are strongly associated with short-term anti-VEGF response in DME. ML models incorporating these features may support individualized treatment assessment, with simpler models offering advantages in robustness and interpretability.

Photodiagnosis and Photodynamic Therapy
Guangzhou University of Chinese Medicine (CN), Third Affiliated Hospital of Southern Medical University (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN), Guangdong Academy of Medical Sciences (CN), Southern Medical University (CN)
Openalex Percentile: Top 8%
Retinal Diseases and Treatments
DOIOpen Access PDFOpenAlex
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Quantitative relative reflectivity features based on OCT for predicting the efficacy of anti-VEGF therapy in Diabetic Macular Edema at 3 months — Guanghua Zhou, Qiaowei Wu, et al. · Photodiagnosis and Photodynamic Therapy (2026) | TGRS Research Map | TGRS