Reply: Lung organoids: a new frontier in neonatology and paediatric respiratory medicine

<title>Extract</title> We would like to thank P. Das and V. Bhandari for their interest in and comments on our recently published review on lung organoids [1]. We welcome the opportunity offered by their thoughtful correspondence to further elaborate on specific aspects of organoid-based research that could not be addressed in our original review, which primarily focused on the strengths and limitations of the model itself. Overall, the authors' comments highlight several challenges associated with research involving substances of human origin (SoHO), including ethical, logistical and biological concerns.