Virtual Clinical Trials in Clinical Medicine: Economic, Ethical, and Practical Considerations

Virtual clinical trials (VCTs) represent an innovative approach to clinical research, using computer simulations and digital modeling rather than traditional human participants. These trials harness computational power and artificial intelligence to model the effects of medical treatments, drastically reducing costs, time, and logistical complexities. As this technology advances, VCTs offer the potential to streamline drug development, enhance precision, and make clinical research more accessible and efficient. However, the shift away from traditional human-based trials raises significant ethical concerns, particularly regarding the validity of results, regulatory oversight, and the potential reduction of human involvement in the research process. This paper explores the economic, ethical, and practical aspects of VCTs in clinical medicine, with a focus on their potential to revolutionize clinical trials and the challenges they present. Future lines of research will also be proposed to address these issues.

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Publication Details

Journal
Reviews on Recent Clinical Trials
Published
2026-03-23
DOI
https://doi.org/10.2174/0115748871436258260114105507
Primary Topic
Digital Mental Health Interventions
Type
article
Field-Weighted Citation Impact
0.00
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article

Virtual Clinical Trials in Clinical Medicine: Economic, Ethical, and Practical Considerations

Dolores Isabel Rexachs, Alvaro Wong, Emilio Luque, Francisco Epelde
Reviews on Recent Clinical Trials
Digital Mental Health Interventions
article

Virtual Clinical Trials in Clinical Medicine: Economic, Ethical, and Practical Considerations

Dolores Isabel Rexachs, Alvaro Wong, Emilio Luque, Francisco Epelde
article en

Abstract

Virtual clinical trials (VCTs) represent an innovative approach to clinical research, using computer simulations and digital modeling rather than traditional human participants. These trials harness computational power and artificial intelligence to model the effects of medical treatments, drastically reducing costs, time, and logistical complexities. As this technology advances, VCTs offer the potential to streamline drug development, enhance precision, and make clinical research more accessible and efficient. However, the shift away from traditional human-based trials raises significant ethical concerns, particularly regarding the validity of results, regulatory oversight, and the potential reduction of human involvement in the research process. This paper explores the economic, ethical, and practical aspects of VCTs in clinical medicine, with a focus on their potential to revolutionize clinical trials and the challenges they present. Future lines of research will also be proposed to address these issues.

Reviews on Recent Clinical TrialsVol. 21
Universitat Autònoma de Barcelona (ES), Institute of Research and Innovation Parc Tauli (ES)
Openalex Percentile: Top 11%
Digital Mental Health Interventions
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